EconomyEnglish7.3/10 · BronzeCSV file availableUpdated 19 Oct 2026

Standard Treatment Workflow on Paediatric Tubercular Meningitis - Question and Answer Dataset

Name: Standard Treatment Workflow on Paediatric Tubercular Meningitis - Question and Answer Dataset
Creator: icmr.gov.in
Keywords: Economy, question-answering, extractive-qa, paediatric-tubercular-meningitis, tubercular-meningitis, icd-10-a17-0, national-tb-elimination-programme, csf-examination, naat, contrast-enhanced-ct-scan, mri-brain, hydrocephalus

#question-answering#extractive-qa#paediatric-tubercular-meningitis#tubercular-meningitis#icd-10-a17-0#national-tb-elimination-programme#csf-examination#naat#contrast-enhanced-ct-scan#mri-brain#hydrocephalus

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About this dataset

22 extractive question-and-answer pairs built from Standard Treatment Workflow on Paediatric Tubercular Meningitis, published by icmr.gov.in. The source is a 1-page publication. Source-evidenced topics include paediatric tubercular meningitis, tubercular meningitis, icd-10-a17.0, national tb elimination programme, csf examination, naat, contrast enhanced ct scan, mri brain. Every answer is a verbatim span of text the source prints, and each row carries the passage it sits in, its offset in that passage, the source quote, the page and the location in the document, so any row can be checked against the original. Question types in the export: 8 definition, 8 list, 6 factual. 16 of the 22 pairs (72.7%) ask explanatory questions; the remaining 6 are factual or table-based questions. 100.00% of rows pass the corpus quality gate.

The story in this dataset

Paediatric Tubercular Meningitis Treatment Workflow Dataset

This dataset contains 22 extractive question-and-answer pairs derived from the Standard Treatment Workflow for Paediatric Tubercular Meningitis, published by icmr.gov.in. It includes definitions, lists, and factual information about diagnostic criteria, treatment protocols, and clinical assessments. The dataset focuses on medical abbreviations, neuroimaging findings, and supportive therapies, providing verbatim excerpts from the source document for verification.

Medical abbreviation VP: Ventriculo-peritoneal

Preview

First 10 of 22 rows

Sample rows from Standard Treatment Workflow on Paediatric Tubercular Meningitis - Question and Answer Dataset
question	answer	context	answer_start	question_type	knowledge_quality_score	source_document	source_quote	source_page	source_location	confidence	validation_status
What does the abbreviation VP stand for in medical terminology?	Ventriculo-peritoneal	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	546	definition	0.940	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells	1	page=1,block=75	0.700	valid
What does the abbreviation AFB stand for?	Acid-fast Bacillus	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	5	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation CBC refer to?	Complete Blood Count	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	29	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation CECT mean?	Contrast Enhanced Computed Tomography	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	56	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation CSF stand for?	Cerebro-spinal Fluid	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	99	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation HRZE stand for?	Isoniazid; Rifampicin; Pyrazinamide; Ethambutol	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	201	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation ICU signify?	Intensive Care Unit	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	254	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation NTEP refer to?	National TB Elimination Programme	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	437	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What are some signs of meningeal irritation that should be checked during an examination?	Neck stiffness, Kernig’s sign & Brudzinski’s sign	• Assessment of sensorium* • Full/bulging anterior fontanelle • Meningeal irritation- Neck stiffness, Kernig’s sign & Brudzinski’s sign • Examine eye, if feasible for papillodema/ choroid tubercles/ optic atrophy • Cranial nerves • Motor system including power, reflexes plantar responses • Peripheral lymph nodes • Chest examination for signs of pulmonary involvement Use any standardized scale including Glasgow Coma scale/ AVPU scale Essential • CBC • CSF examination › Cell count and differential › Sugar (with simultaneous blood sugar) › Protein › NAAT › MGIT culture › Bacterial culture • HIV • Contrast enhanced CT scan of head • CXR • Gastric lavage/ Induced sputum in patients where CXR is abnormal and CSF NAAT is negative *ICMR/NTEP approved NAAT test, use 3-5 ml CSF if possible Desirable • MRI brain with contrast when CECT head is not contributory	86	list	0.820	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	• Assessment of sensorium* • Full/bulging anterior fontanelle • Meningeal irritation- Neck stiffness, Kernig’s sign & Brudzinski’s sign • Examine eye, if feasible for papillodema/ choroid tubercles/ optic atrophy • Cranial nerves • Motor system including power, reflexes plantar responses • Peripheral lymph nodes • Chest examination for signs of pulmonary involvement Use any standardized scale including Glasgow Coma scale/ AVPU scale Essential • CBC • CSF examination › Cell count and differential › Sugar (with simultaneous blood sugar) › Protein › NAAT › MGIT culture › Bacterial culture •
What are the neuroimaging findings that meet Criterion 1 for starting treatment?	Basal exudates › Hydrocephalus › Infarct › Tuberculoma	• Immediate investigations • CBC, HIV • CECT head • CSF: Cell count including differential, CSF sugar (with blood sugar), protein, NAAT, bacterial culture • CXR Criterion 1 ≥3 of the following • ≥5 days of symptoms as above • TLC < 15,000/ cumm • CSF WBC 10-500/ cumm • CSF sugar < 50% of blood sugar • CSF lymphocytes >50% • Neuroimaging finding of (one or more) : › Basal exudates › Hydrocephalus › Infarct › Tuberculoma Criterion 2- Criteria positive if at least 2 of the following 3 risk factors are present • HIV infection • Severe acute malnutrition • Recent contact with infectious TB Criterion 3 • Evidence of TB elsewhere AFB seen/CSF NAAT +ve (Microbiologically confirmed TBM) Start treatment 2 or more criteria met Continue investigations & management for partially treated bacterial meningitis	368	list	0.820	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	• Immediate investigations • CBC, HIV • CECT head • CSF: Cell count including differential, CSF sugar (with blood sugar), protein, NAAT, bacterial culture • CXR Criterion 1 ≥3 of the following • ≥5 days of symptoms as above • TLC < 15,000/ cumm • CSF WBC 10-500/ cumm • CSF sugar < 50% of blood sugar • CSF lymphocytes >50% • Neuroimaging finding of (one or more) : › Basal exudates › Hydrocephalus › Infarct › Tuberculoma Criterion 2- Criteria positive if at least 2 of the following 3 risk factors are present • HIV infection • Severe acute malnutrition • Recent contact with infectious TB

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First 10 of 22 rows

Sample rows from Standard Treatment Workflow on Paediatric Tubercular Meningitis - Question and Answer Dataset
question	answer	context	answer_start	question_type	knowledge_quality_score	source_document	source_quote	source_page	source_location	confidence	validation_status
What does the abbreviation VP stand for in medical terminology?	Ventriculo-peritoneal	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	546	definition	0.940	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells	1	page=1,block=75	0.700	valid
What does the abbreviation AFB stand for?	Acid-fast Bacillus	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	5	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation CBC refer to?	Complete Blood Count	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	29	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation CECT mean?	Contrast Enhanced Computed Tomography	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	56	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation CSF stand for?	Cerebro-spinal Fluid	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	99	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation HRZE stand for?	Isoniazid; Rifampicin; Pyrazinamide; Ethambutol	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	201	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation ICU signify?	Intensive Care Unit	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	254	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What does the abbreviation NTEP refer to?	National TB Elimination Programme	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells REFERENCES	437	definition	0.900	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	AFB: Acid-fast Bacillus CBC: Complete Blood Count CECT: Contrast Enhanced Computed Tomography CSF: Cerebro-spinal Fluid CT: Computed Tomography CXR: Chest X-ray HIV: Human Immunodeficiency Virus HRZE: Isoniazid; Rifampicin; Pyrazinamide; Ethambutol ICU: Intensive Care Unit LP: Lumbar Puncture MDR: Multi-drug Resistant MGIT: Mycobacteria Growth Indicator Tube MRI: Magnetic Resonance Imaging NAAT: Nucleic Acid Amplification Test NTEP: National TB Elimination Programme TB: Tuberculosis TBM: Tubercular Meningitis TLC: Total Leucocyte Count VP: Ventriculo-peritoneal WBC: White Blood Cells
What are some signs of meningeal irritation that should be checked during an examination?	Neck stiffness, Kernig’s sign & Brudzinski’s sign	• Assessment of sensorium* • Full/bulging anterior fontanelle • Meningeal irritation- Neck stiffness, Kernig’s sign & Brudzinski’s sign • Examine eye, if feasible for papillodema/ choroid tubercles/ optic atrophy • Cranial nerves • Motor system including power, reflexes plantar responses • Peripheral lymph nodes • Chest examination for signs of pulmonary involvement Use any standardized scale including Glasgow Coma scale/ AVPU scale Essential • CBC • CSF examination › Cell count and differential › Sugar (with simultaneous blood sugar) › Protein › NAAT › MGIT culture › Bacterial culture • HIV • Contrast enhanced CT scan of head • CXR • Gastric lavage/ Induced sputum in patients where CXR is abnormal and CSF NAAT is negative *ICMR/NTEP approved NAAT test, use 3-5 ml CSF if possible Desirable • MRI brain with contrast when CECT head is not contributory	86	list	0.820	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	• Assessment of sensorium* • Full/bulging anterior fontanelle • Meningeal irritation- Neck stiffness, Kernig’s sign & Brudzinski’s sign • Examine eye, if feasible for papillodema/ choroid tubercles/ optic atrophy • Cranial nerves • Motor system including power, reflexes plantar responses • Peripheral lymph nodes • Chest examination for signs of pulmonary involvement Use any standardized scale including Glasgow Coma scale/ AVPU scale Essential • CBC • CSF examination › Cell count and differential › Sugar (with simultaneous blood sugar) › Protein › NAAT › MGIT culture › Bacterial culture •
What are the neuroimaging findings that meet Criterion 1 for starting treatment?	Basal exudates › Hydrocephalus › Infarct › Tuberculoma	• Immediate investigations • CBC, HIV • CECT head • CSF: Cell count including differential, CSF sugar (with blood sugar), protein, NAAT, bacterial culture • CXR Criterion 1 ≥3 of the following • ≥5 days of symptoms as above • TLC < 15,000/ cumm • CSF WBC 10-500/ cumm • CSF sugar < 50% of blood sugar • CSF lymphocytes >50% • Neuroimaging finding of (one or more) : › Basal exudates › Hydrocephalus › Infarct › Tuberculoma Criterion 2- Criteria positive if at least 2 of the following 3 risk factors are present • HIV infection • Severe acute malnutrition • Recent contact with infectious TB Criterion 3 • Evidence of TB elsewhere AFB seen/CSF NAAT +ve (Microbiologically confirmed TBM) Start treatment 2 or more criteria met Continue investigations & management for partially treated bacterial meningitis	368	list	0.820	https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964680_5_paediatric_tubercular_meningitis.pdf	• Immediate investigations • CBC, HIV • CECT head • CSF: Cell count including differential, CSF sugar (with blood sugar), protein, NAAT, bacterial culture • CXR Criterion 1 ≥3 of the following • ≥5 days of symptoms as above • TLC < 15,000/ cumm • CSF WBC 10-500/ cumm • CSF sugar < 50% of blood sugar • CSF lymphocytes >50% • Neuroimaging finding of (one or more) : › Basal exudates › Hydrocephalus › Infarct › Tuberculoma Criterion 2- Criteria positive if at least 2 of the following 3 risk factors are present • HIV infection • Severe acute malnutrition • Recent contact with infectious TB

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Standard Treatment Workflow on Paediatric Tubercular Meningitis - Question and Answer Dataset

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