| What is the composition of the dispersible FDC containing three drugs for paediatric use? | Rifampicin 75 mg + Isoniazid 50 mg + Pyrazinamide 150 mg | Those weighing more than 39 kg to be treated with adult weight bands. Available paediatric dispersible FDCs and loose drugs 1. Dispersible FDC, flavoured • Rifampicin 75 mg + Isoniazid 50 mg + Pyrazinamide 150 mg • Rifampicin 75 mg + Isoniazid 50 mg 2. Dispersible Loose drugs • Ethambutol 100 mg • Isoniazid 100 mg • *A=Adult FDC (HRZE = 75/150/400/275; HRE = 75/150/275). | 156 | list | 0.820 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf | Dispersible FDC, flavoured • Rifampicin 75 mg + Isoniazid 50 mg + Pyrazinamide 150 mg • Rifampicin 75 mg + Isoniazid 50 mg 2. | 1 | page=1,block=58 | 0.700 | valid |
| What corticosteroid dosage is recommended for paediatric TB meningitis? | Prednisolone 2 mg/kg/day for 4 weeks & then taper over 4 weeks | It is added in higher weight band categories i.e. > 25 kg as these children may be able to swallow tablets • Pyridoxine may be given at a dosage of 10 mg per day Special considerations for paediatric osteoarticular TB • Regimen : 2HRZE + 10HRE • Follow up every month during treatment & subsequently every 3 months: Potts spine with X-ray or MRI & Tubercular dactylitis or arthritis with plain X-ray Special considerations for paediatric TB meningitis ATT for paediatric TB Meningitis › 2 HRZE and 10 HRE (in appropriate doses) Corticosteroids › Prednisolone 2 mg/kg/day for 4 weeks & then taper over 4 weeks* › Slower taper needed in some patients *Equivalent dose of another steroid formulation may be used either injectable/oral | 546 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf | > 25 kg as these children may be able to swallow tablets • Pyridoxine may be given at a dosage of 10 mg per day Special considerations for paediatric osteoarticular TB • Regimen : 2HRZE + 10HRE • Follow up every month during treatment & subsequently every 3 months: Potts spine with X-ray or MRI & Tubercular dactylitis or arthritis with plain X-ray Special considerations for paediatric TB meningitis ATT for paediatric TB Meningitis › 2 HRZE and 10 HRE (in appropriate doses) Corticosteroids › Prednisolone 2 mg/kg/day for 4 weeks & then taper over 4 weeks* › Slower taper needed in some patients |
| What is the follow-up schedule for paediatric osteoarticular TB involving Potts spine? | every month during treatment & subsequently every 3 months: Potts spine with X-ray or MRI | It is added in higher weight band categories i.e. > 25 kg as these children may be able to swallow tablets • Pyridoxine may be given at a dosage of 10 mg per day Special considerations for paediatric osteoarticular TB • Regimen : 2HRZE + 10HRE • Follow up every month during treatment & subsequently every 3 months: Potts spine with X-ray or MRI & Tubercular dactylitis or arthritis with plain X-ray Special considerations for paediatric TB meningitis ATT for paediatric TB Meningitis › 2 HRZE and 10 HRE (in appropriate doses) Corticosteroids › Prednisolone 2 mg/kg/day for 4 weeks & then taper over 4 weeks* › Slower taper needed in some patients *Equivalent dose of another steroid formulation may be used either injectable/oral | 256 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf | > 25 kg as these children may be able to swallow tablets • Pyridoxine may be given at a dosage of 10 mg per day Special considerations for paediatric osteoarticular TB • Regimen : 2HRZE + 10HRE • Follow up every month during treatment & subsequently every 3 months: Potts spine with X-ray or MRI & Tubercular dactylitis or arthritis with plain X-ray Special considerations for paediatric TB meningitis ATT for paediatric TB Meningitis › 2 HRZE and 10 HRE (in appropriate doses) Corticosteroids › Prednisolone 2 mg/kg/day for 4 weeks & then taper over 4 weeks* › Slower taper needed in some patients |
| What is the preferred medication and dosage for intravenous treatment during a hospital stay for certain conditions? | Dexamethasone 0.4 mg/kg/day intravenously in 3-4 divided doses | *treatment duration may be increased in some cases as per the clinician decision › Preferably Dexamethasone 0.4 mg/kg/day intravenously in 3-4 divided doses during hospital stay › If not feasible, give oral Dexamethasone 0.4 mg/kg/day in divided doses or oral Prednisolone 1 mg/kg/day in a single morning dose › Discharge on oral steroids on tapering doses for total duration of 8-12 weeks › Regular follow up is essential every month for at least first 3 months & can be increased thereafter till treatment is stopped › Monitor liver function tests & any other features of drug toxicity › Observe for clinical improvement or any deterioration › Closely observe for development of any complications Special considerations for Adult abdominal TB • Extend duration of treatment in cases of inadequate response • Refer for surgical management for complications [intestinal obstruction (due to strictures), perforation] • Consider endoscopic dilatation for treatment for accessible strictures • Refer for biliary drainage in case of Jaundice due to biliary obstruction (hepatobiliary obstruction/pancreatic TB) Special considerations for intra-ocular TB | 94 | factual | 0.570 |
| What is the recommended dosage of oral Prednisolone for certain conditions? | oral Prednisolone 1 mg/kg/day in a single morning dose | *treatment duration may be increased in some cases as per the clinician decision › Preferably Dexamethasone 0.4 mg/kg/day intravenously in 3-4 divided doses during hospital stay › If not feasible, give oral Dexamethasone 0.4 mg/kg/day in divided doses or oral Prednisolone 1 mg/kg/day in a single morning dose › Discharge on oral steroids on tapering doses for total duration of 8-12 weeks › Regular follow up is essential every month for at least first 3 months & can be increased thereafter till treatment is stopped › Monitor liver function tests & any other features of drug toxicity › Observe for clinical improvement or any deterioration › Closely observe for development of any complications Special considerations for Adult abdominal TB • Extend duration of treatment in cases of inadequate response • Refer for surgical management for complications [intestinal obstruction (due to strictures), perforation] • Consider endoscopic dilatation for treatment for accessible strictures • Refer for biliary drainage in case of Jaundice due to biliary obstruction (hepatobiliary obstruction/pancreatic TB) Special considerations for intra-ocular TB | 255 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf |
| What is the suggested follow-up frequency after the first three months of treatment? | can be increased thereafter till treatment is stopped | *treatment duration may be increased in some cases as per the clinician decision › Preferably Dexamethasone 0.4 mg/kg/day intravenously in 3-4 divided doses during hospital stay › If not feasible, give oral Dexamethasone 0.4 mg/kg/day in divided doses or oral Prednisolone 1 mg/kg/day in a single morning dose › Discharge on oral steroids on tapering doses for total duration of 8-12 weeks › Regular follow up is essential every month for at least first 3 months & can be increased thereafter till treatment is stopped › Monitor liver function tests & any other features of drug toxicity › Observe for clinical improvement or any deterioration › Closely observe for development of any complications Special considerations for Adult abdominal TB • Extend duration of treatment in cases of inadequate response • Refer for surgical management for complications [intestinal obstruction (due to strictures), perforation] • Consider endoscopic dilatation for treatment for accessible strictures • Refer for biliary drainage in case of Jaundice due to biliary obstruction (hepatobiliary obstruction/pancreatic TB) Special considerations for intra-ocular TB | 465 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf |
| What is the total duration for tapering doses of oral steroids after discharge? | total duration of 8-12 weeks | *treatment duration may be increased in some cases as per the clinician decision › Preferably Dexamethasone 0.4 mg/kg/day intravenously in 3-4 divided doses during hospital stay › If not feasible, give oral Dexamethasone 0.4 mg/kg/day in divided doses or oral Prednisolone 1 mg/kg/day in a single morning dose › Discharge on oral steroids on tapering doses for total duration of 8-12 weeks › Regular follow up is essential every month for at least first 3 months & can be increased thereafter till treatment is stopped › Monitor liver function tests & any other features of drug toxicity › Observe for clinical improvement or any deterioration › Closely observe for development of any complications Special considerations for Adult abdominal TB • Extend duration of treatment in cases of inadequate response • Refer for surgical management for complications [intestinal obstruction (due to strictures), perforation] • Consider endoscopic dilatation for treatment for accessible strictures • Refer for biliary drainage in case of Jaundice due to biliary obstruction (hepatobiliary obstruction/pancreatic TB) Special considerations for intra-ocular TB | 361 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf |
| How often should follow-up occur during the first three months of treatment? | every month | *treatment duration may be increased in some cases as per the clinician decision › Preferably Dexamethasone 0.4 mg/kg/day intravenously in 3-4 divided doses during hospital stay › If not feasible, give oral Dexamethasone 0.4 mg/kg/day in divided doses or oral Prednisolone 1 mg/kg/day in a single morning dose › Discharge on oral steroids on tapering doses for total duration of 8-12 weeks › Regular follow up is essential every month for at least first 3 months & can be increased thereafter till treatment is stopped › Monitor liver function tests & any other features of drug toxicity › Observe for clinical improvement or any deterioration › Closely observe for development of any complications Special considerations for Adult abdominal TB • Extend duration of treatment in cases of inadequate response • Refer for surgical management for complications [intestinal obstruction (due to strictures), perforation] • Consider endoscopic dilatation for treatment for accessible strictures • Refer for biliary drainage in case of Jaundice due to biliary obstruction (hepatobiliary obstruction/pancreatic TB) Special considerations for intra-ocular TB | 423 | factual | 0.490 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf |
| What is the dosage of Pyridoxine recommended for children in higher weight band categories? | 10 mg per day | It is added in higher weight band categories i.e. > 25 kg as these children may be able to swallow tablets • Pyridoxine may be given at a dosage of 10 mg per day Special considerations for paediatric osteoarticular TB • Regimen : 2HRZE + 10HRE • Follow up every month during treatment & subsequently every 3 months: Potts spine with X-ray or MRI & Tubercular dactylitis or arthritis with plain X-ray Special considerations for paediatric TB meningitis ATT for paediatric TB Meningitis › 2 HRZE and 10 HRE (in appropriate doses) Corticosteroids › Prednisolone 2 mg/kg/day for 4 weeks & then taper over 4 weeks* › Slower taper needed in some patients *Equivalent dose of another steroid formulation may be used either injectable/oral | 148 | factual | 0.490 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf | > 25 kg as these children may be able to swallow tablets • Pyridoxine may be given at a dosage of 10 mg per day Special considerations for paediatric osteoarticular TB • Regimen : 2HRZE + 10HRE • Follow up every month during treatment & subsequently every 3 months: Potts spine with X-ray or MRI & Tubercular dactylitis or arthritis with plain X-ray Special considerations for paediatric TB meningitis ATT for paediatric TB Meningitis › 2 HRZE and 10 HRE (in appropriate doses) Corticosteroids › Prednisolone 2 mg/kg/day for 4 weeks & then taper over 4 weeks* › Slower taper needed in some patients |
| What should be monitored during treatment to detect drug toxicity? | liver function tests | *treatment duration may be increased in some cases as per the clinician decision › Preferably Dexamethasone 0.4 mg/kg/day intravenously in 3-4 divided doses during hospital stay › If not feasible, give oral Dexamethasone 0.4 mg/kg/day in divided doses or oral Prednisolone 1 mg/kg/day in a single morning dose › Discharge on oral steroids on tapering doses for total duration of 8-12 weeks › Regular follow up is essential every month for at least first 3 months & can be increased thereafter till treatment is stopped › Monitor liver function tests & any other features of drug toxicity › Observe for clinical improvement or any deterioration › Closely observe for development of any complications Special considerations for Adult abdominal TB • Extend duration of treatment in cases of inadequate response • Refer for surgical management for complications [intestinal obstruction (due to strictures), perforation] • Consider endoscopic dilatation for treatment for accessible strictures • Refer for biliary drainage in case of Jaundice due to biliary obstruction (hepatobiliary obstruction/pancreatic TB) Special considerations for intra-ocular TB | 529 | factual | 0.490 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964686_2_ntep_18032022.pdf |