| What conditions should be ruled out if there is non-response to abdominal tuberculosis treatment? | Crohn's disease OR Inflammatory Bowel Disease | • No response to appropriate treatment • Oral drug (ATT) intolerance/cannot be given MONITORING • Assessment of response to treatment: › Clinical follow up - every month during treatment & after that every 3 months › Radiologically by USG - At the end of treatment or if worsening or non response to treatment › Microbiological - If worsening or non response to treatment • Pointers towards DR TB investigation: › Non response to treatment or Worsening or deterioration of constitutional symptoms after initial improvement. Rule out Crohn's disease OR Inflammatory Bowel Disease • Obstructive symptoms may persist or worsen despite treatment with appropriate ATT • Monitor for › Adherence to treatment (ATT) › Adverse drug reactions- ATT induced | 533 | list | 0.820 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf | Rule out Crohn's disease OR Inflammatory Bowel Disease • Obstructive symptoms may persist or worsen despite treatment with appropriate ATT • Monitor for › Adherence to treatment (ATT) › Adverse drug reactions- ATT induced | 1 | page=1,block=16 | 0.700 | valid |
| What diagnostic tests are recommended if exudative ascites is detected in abdominal tuberculosis? | ascitic fluid for NAAT, TB culture | CLINICAL FEATURES SPECIFIC TO TYPE OF ABDOMINAL TB RED FLAGS • Pain abdomen waking child from sleep • Chronic, severe, or nocturnal diarrhea • Presence of constitutional symptoms like fever, anorexia, weight loss, etc. • Localized distension or mass ESSENTIAL • Ultrasound abdomen Ascites Essential • If exudative ascites, ascitic fluid for NAAT, TB culture • No role of ADA Enlarged Abdominal mass Desirable • USG guided Abdominal mass-FNA for cytology, NAAT, TB culture Optional • USG/CT guided core biopsy of LN for histology, NAAT, TB culture Intestinal involvement Desirable • CECT Abdomen/CT enterography • USG guided Abdominal Mass -FNA for cytology, NAAT, culture Optional • Ileocolonoscopy, tissue biopsy (HPE, NAAT) • Laparoscopy, tissue biopsy for HPE, NAAT | 323 | list | 0.820 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf | • Localized distension or mass ESSENTIAL • Ultrasound abdomen Ascites Essential • If exudative ascites, ascitic fluid for NAAT, TB culture • No role of ADA Enlarged Abdominal mass Desirable • USG guided Abdominal mass-FNA for cytology, NAAT, TB culture Optional • USG/CT guided core biopsy of LN for histology, NAAT, TB culture Intestinal involvement Desirable • CECT Abdomen/CT enterography • USG guided Abdominal Mass -FNA for cytology, NAAT, culture Optional • Ileocolonoscopy, tissue biopsy (HPE, NAAT) • Laparoscopy, tissue biopsy for HPE, NAAT |
| What optional diagnostic methods are available for histology and NAAT in cases of intestinal involvement in abdominal tuberculosis? | Ileocolonoscopy, tissue biopsy (HPE, NAAT) • Laparoscopy, tissue biopsy for HPE, NAAT | CLINICAL FEATURES SPECIFIC TO TYPE OF ABDOMINAL TB RED FLAGS • Pain abdomen waking child from sleep • Chronic, severe, or nocturnal diarrhea • Presence of constitutional symptoms like fever, anorexia, weight loss, etc. • Localized distension or mass ESSENTIAL • Ultrasound abdomen Ascites Essential • If exudative ascites, ascitic fluid for NAAT, TB culture • No role of ADA Enlarged Abdominal mass Desirable • USG guided Abdominal mass-FNA for cytology, NAAT, TB culture Optional • USG/CT guided core biopsy of LN for histology, NAAT, TB culture Intestinal involvement Desirable • CECT Abdomen/CT enterography • USG guided Abdominal Mass -FNA for cytology, NAAT, culture Optional • Ileocolonoscopy, tissue biopsy (HPE, NAAT) • Laparoscopy, tissue biopsy for HPE, NAAT | 683 | list | 0.820 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf | • Localized distension or mass ESSENTIAL • Ultrasound abdomen Ascites Essential • If exudative ascites, ascitic fluid for NAAT, TB culture • No role of ADA Enlarged Abdominal mass Desirable • USG guided Abdominal mass-FNA for cytology, NAAT, TB culture Optional • USG/CT guided core biopsy of LN for histology, NAAT, TB culture Intestinal involvement Desirable • CECT Abdomen/CT enterography • USG guided Abdominal Mass -FNA for cytology, NAAT, culture Optional • Ileocolonoscopy, tissue biopsy (HPE, NAAT) • Laparoscopy, tissue biopsy for HPE, NAAT |
| What physical findings might be observed in a patient with abdominal tuberculosis? | peripheral LAP, ascites, hepatosplenomegaly, doughy feel of abdomen, palpable abdominal lump, visible peristalsis or a moving mass | • Anthropometry • General physical & systemic examination • Look for peripheral LAP, ascites, hepatosplenomegaly, doughy feel of abdomen, palpable abdominal lump, visible peristalsis or a moving mass -"gola" formation due to partially obstructed dilated bowel loop • One or more of following › Recurrent/chronic abdominal pain in presence of red flag signs › Abdominal distension/mass › Altered bowel habits • Constitutional symptoms like Presence of Fever >2 weeks, Anorexia, Unexplained weight loss or no weight gain in last 3 months despite adequate nutrition may be present • History of contact with TB patient may also be present • Recurrent intestinal colic • Altered bowel habits • Chronic diarrhoea • Partial/complete intestinal obstruction • Weight loss, anorexia • Palpable abdominal lump • Lower gastrointestinal bleeding • Abdominal pain • Fever • Jaundice • Weight loss • Anorexia • Hepatomegaly • Splenomegaly • Hepatic abscess • Palpable abdominal lump • Abnormal LFTs WHEN TO SUSPECT? | 69 | list | 0.820 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf |
| What symptoms might indicate the presence of constitutional signs in abdominal tuberculosis? | Fever >2 weeks, Anorexia, Unexplained weight loss or no weight gain in last 3 months despite adequate nutrition | • Anthropometry • General physical & systemic examination • Look for peripheral LAP, ascites, hepatosplenomegaly, doughy feel of abdomen, palpable abdominal lump, visible peristalsis or a moving mass -"gola" formation due to partially obstructed dilated bowel loop • One or more of following › Recurrent/chronic abdominal pain in presence of red flag signs › Abdominal distension/mass › Altered bowel habits • Constitutional symptoms like Presence of Fever >2 weeks, Anorexia, Unexplained weight loss or no weight gain in last 3 months despite adequate nutrition may be present • History of contact with TB patient may also be present • Recurrent intestinal colic • Altered bowel habits • Chronic diarrhoea • Partial/complete intestinal obstruction • Weight loss, anorexia • Palpable abdominal lump • Lower gastrointestinal bleeding • Abdominal pain • Fever • Jaundice • Weight loss • Anorexia • Hepatomegaly • Splenomegaly • Hepatic abscess • Palpable abdominal lump • Abnormal LFTs WHEN TO SUSPECT? | 451 | list | 0.820 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf |
| What imaging techniques are desirable for assessing intestinal involvement in abdominal tuberculosis? | CECT Abdomen/CT enterography | CLINICAL FEATURES SPECIFIC TO TYPE OF ABDOMINAL TB RED FLAGS • Pain abdomen waking child from sleep • Chronic, severe, or nocturnal diarrhea • Presence of constitutional symptoms like fever, anorexia, weight loss, etc. • Localized distension or mass ESSENTIAL • Ultrasound abdomen Ascites Essential • If exudative ascites, ascitic fluid for NAAT, TB culture • No role of ADA Enlarged Abdominal mass Desirable • USG guided Abdominal mass-FNA for cytology, NAAT, TB culture Optional • USG/CT guided core biopsy of LN for histology, NAAT, TB culture Intestinal involvement Desirable • CECT Abdomen/CT enterography • USG guided Abdominal Mass -FNA for cytology, NAAT, culture Optional • Ileocolonoscopy, tissue biopsy (HPE, NAAT) • Laparoscopy, tissue biopsy for HPE, NAAT | 582 | list | 0.740 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf | • Localized distension or mass ESSENTIAL • Ultrasound abdomen Ascites Essential • If exudative ascites, ascitic fluid for NAAT, TB culture • No role of ADA Enlarged Abdominal mass Desirable • USG guided Abdominal mass-FNA for cytology, NAAT, TB culture Optional • USG/CT guided core biopsy of LN for histology, NAAT, TB culture Intestinal involvement Desirable • CECT Abdomen/CT enterography • USG guided Abdominal Mass -FNA for cytology, NAAT, culture Optional • Ileocolonoscopy, tissue biopsy (HPE, NAAT) • Laparoscopy, tissue biopsy for HPE, NAAT |
| How often should clinical follow-up be conducted during and after treatment for abdominal tuberculosis? | every month during treatment & after that every 3 months | • No response to appropriate treatment • Oral drug (ATT) intolerance/cannot be given MONITORING • Assessment of response to treatment: › Clinical follow up - every month during treatment & after that every 3 months › Radiologically by USG - At the end of treatment or if worsening or non response to treatment › Microbiological - If worsening or non response to treatment • Pointers towards DR TB investigation: › Non response to treatment or Worsening or deterioration of constitutional symptoms after initial improvement. Rule out Crohn's disease OR Inflammatory Bowel Disease • Obstructive symptoms may persist or worsen despite treatment with appropriate ATT • Monitor for › Adherence to treatment (ATT) › Adverse drug reactions- ATT induced | 158 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf | • No response to appropriate treatment • Oral drug (ATT) intolerance/cannot be given MONITORING • Assessment of response to treatment: › Clinical follow up - every month during treatment & after that every 3 months › Radiologically by USG - At the end of treatment or if worsening or non response to treatment › Microbiological - If worsening or non response to treatment • Pointers towards DR TB investigation: › Non response to treatment or Worsening or deterioration of constitutional symptoms after initial improvement. |
| What are the pointers towards investigating drug-resistant tuberculosis in abdominal TB cases? | Non response to treatment or Worsening or deterioration of constitutional symptoms after initial improvement | • No response to appropriate treatment • Oral drug (ATT) intolerance/cannot be given MONITORING • Assessment of response to treatment: › Clinical follow up - every month during treatment & after that every 3 months › Radiologically by USG - At the end of treatment or if worsening or non response to treatment › Microbiological - If worsening or non response to treatment • Pointers towards DR TB investigation: › Non response to treatment or Worsening or deterioration of constitutional symptoms after initial improvement. Rule out Crohn's disease OR Inflammatory Bowel Disease • Obstructive symptoms may persist or worsen despite treatment with appropriate ATT • Monitor for › Adherence to treatment (ATT) › Adverse drug reactions- ATT induced | 414 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf | • No response to appropriate treatment • Oral drug (ATT) intolerance/cannot be given MONITORING • Assessment of response to treatment: › Clinical follow up - every month during treatment & after that every 3 months › Radiologically by USG - At the end of treatment or if worsening or non response to treatment › Microbiological - If worsening or non response to treatment • Pointers towards DR TB investigation: › Non response to treatment or Worsening or deterioration of constitutional symptoms after initial improvement. |
| What are the radiological methods used to assess the response to treatment for abdominal tuberculosis? | Radiologically by USG - At the end of treatment or if worsening or non response to treatment | • No response to appropriate treatment • Oral drug (ATT) intolerance/cannot be given MONITORING • Assessment of response to treatment: › Clinical follow up - every month during treatment & after that every 3 months › Radiologically by USG - At the end of treatment or if worsening or non response to treatment › Microbiological - If worsening or non response to treatment • Pointers towards DR TB investigation: › Non response to treatment or Worsening or deterioration of constitutional symptoms after initial improvement. Rule out Crohn's disease OR Inflammatory Bowel Disease • Obstructive symptoms may persist or worsen despite treatment with appropriate ATT • Monitor for › Adherence to treatment (ATT) › Adverse drug reactions- ATT induced | 217 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf | • No response to appropriate treatment • Oral drug (ATT) intolerance/cannot be given MONITORING • Assessment of response to treatment: › Clinical follow up - every month during treatment & after that every 3 months › Radiologically by USG - At the end of treatment or if worsening or non response to treatment › Microbiological - If worsening or non response to treatment • Pointers towards DR TB investigation: › Non response to treatment or Worsening or deterioration of constitutional symptoms after initial improvement. |
| What is the recommended duration for ATT treatment in the management of abdominal tuberculosis? | 6 months (2HRZE + 4HRE) | SPLEEN, PANCREAS) • Abdominal pain, distension • Fever • Weight loss TREATMENT • Start treatment & follow-up as per NTEP • ATT for 6 months (2HRZE + 4HRE) • Pyridoxine supplementation- 10 mg/day • Steroids- Routinely not recommended (SAIO) • Supportive treatment- Management of SAM/Malnutrition as per national guidelines • Surgical treatment: › Acute intestinal obstruction, Bowel perforation › Persistence of obstructive symptoms despite conservative management & ATT | 131 | factual | 0.570 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1725964684_1_paediatric_abdominal_tb.pdf | SPLEEN, PANCREAS) • Abdominal pain, distension • Fever • Weight loss TREATMENT • Start treatment & follow-up as per NTEP • ATT for 6 months (2HRZE + 4HRE) • Pyridoxine supplementation- 10 mg/day • Steroids- Routinely not recommended (SAIO) • Supportive treatment- Management of SAM/Malnutrition as per national guidelines • Surgical treatment: › Acute intestinal obstruction, Bowel perforation › Persistence of obstructive symptoms despite conservative management & ATT | 1 | page=1,block=8 |