| What does the abbreviation HER2 refer to? | Human epidermal growth factor receptor 2 | Primary systemic therapy ALND: Axillary lymph node dissection CECT: Contrast-enhanced computed tomography ER/PR: Estrogen receptor/Progesterone receptor FISH: Fluorescence in situ hybridization HER2: Human epidermal growth factor receptor 2 IHC: Immunohistochemistry MBC: Metastatic breast cancer PET-CT: Positron emission tomography- computed tomography scan RT: Radiotherapy SLNB: Sentinel lymph node biopsy | 200 | definition | 0.980 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | Primary systemic therapy ALND: Axillary lymph node dissection CECT: Contrast-enhanced computed tomography ER/PR: Estrogen receptor/Progesterone receptor FISH: Fluorescence in situ hybridization HER2: Human epidermal growth factor receptor 2 IHC: Immunohistochemistry MBC: Metastatic breast cancer PET-CT: Positron emission tomography- computed tomography scan RT: Radiotherapy SLNB: Sentinel lymph node biopsy | 8 | page=8,block=69 | 0.700 | valid |
| What might influence variations in the management of an individual patient? | his/her specific condition, as decided by the treating physician. | These STWs have been prepared by national experts of India with feasibility considerations for various levels of healthcare system in the country. These broad guidelines are advisory, and are based on expert opinions and available scientific evidence. There may be variations in the management of an individual patient based on his/her specific condition, as decided by the treating physician. There will be no indemnity for direct or indirect consequences. Kindly visit our web portal (stw.icmr.org.in) for more information. | 328 | relationship | 0.970 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | There may be variations in the management of an individual patient based on his/her specific condition, as decided by the treating physician. There will be no indemnity for direct or indirect consequences. | 3 | page=3,block=1 | 0.700 | valid |
| What benefit does screening provide for oral premalignant disorders and invasive cancer? | detect OPMD and invasive cancer early and improve outcome | • Tobacco • Alcohol • Areca nut • Sharp tooth • Ill-fitting dentures Non healing ulcer/ sore in the mouth especially in a tobacco chewer or smoker Oral premalignant disorders (OPMD): leukoplakia/ erythroplakia/sub mucous fibrosis, lichen planus Neck mass Difficulty in opening mouth Difficulty in protrusion of tongue Pain referred to ear Screening can detect OPMD and invasive cancer early and improve outcome. | 353 | summary | 0.970 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | • Tobacco • Alcohol • Areca nut • Sharp tooth • Ill-fitting dentures Non healing ulcer/ sore in the mouth especially in a tobacco chewer or smoker Oral premalignant disorders (OPMD): leukoplakia/ erythroplakia/sub mucous fibrosis, lichen planus Neck mass Difficulty in opening mouth Difficulty in protrusion of tongue Pain referred to ear Screening can detect OPMD and invasive cancer early and improve outcome. | 10 | page=10,block=3 | 0.700 | valid |
| What is the focus of the efforts to decode complex guidelines in India's healthcare system? | disease management protocols and pre-defined referral mechanisms | Ministry of Health and Family Welfare, Government of India To empower the primary, secondary and tertiary health care physicians/surgeons towards achieving the overall goal of Universal Health Coverage with disease management protocols and pre-defined referral mechanisms by decoding complex guidelines. | 207 | summary | 0.970 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | Ministry of Health and Family Welfare, Government of India To empower the primary, secondary and tertiary health care physicians/surgeons towards achieving the overall goal of Universal Health Coverage with disease management protocols and pre-defined referral mechanisms by decoding complex guidelines. | 6 | page=6,block=11 | 0.700 | valid |
| What is the goal of empowering healthcare physicians and surgeons in India? | achieving the overall goal of Universal Health Coverage | Ministry of Health and Family Welfare, Government of India To empower the primary, secondary and tertiary health care physicians/surgeons towards achieving the overall goal of Universal Health Coverage with disease management protocols and pre-defined referral mechanisms by decoding complex guidelines. | 146 | summary | 0.970 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | Ministry of Health and Family Welfare, Government of India To empower the primary, secondary and tertiary health care physicians/surgeons towards achieving the overall goal of Universal Health Coverage with disease management protocols and pre-defined referral mechanisms by decoding complex guidelines. | 6 | page=6,block=11 | 0.700 | valid |
| What is the preferred initial treatment for T1 T2, N0 cancers with curative intent? | Initial surgery preferred (wide excision with 1 cm margins & supra-omohyoid neck dissection (Level I – III) with reconstruction | BASE/ INTERNAL CAROTID ARTERY INVOLVEMENT T1 T2, N0 CANCER OPTIONS WITH CURATIVE INTENT Initial surgery preferred (wide excision with 1 cm margins & supra-omohyoid neck dissection (Level I – III) with reconstruction OR Radical radiation therapy OPTIONS WITH CURATIVE INTENT Initial surgery: wide excision with 1 cm margins + comprehensive neck dissection and reconstruction OR Chemoradiation OR Neo-adjuvant CT followed by surgery INDICATIONS FOR ADJUVANT RT Close margin, positive node(s), or presence of any two of following: LVI, PNI, high grade INDICATIONS FOR ADJUVANT CT-RT: Metastatic nodes with extracapsular extension, involved margins | 88 | summary | 0.970 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | BASE/ INTERNAL CAROTID ARTERY INVOLVEMENT T1 T2, N0 CANCER OPTIONS WITH CURATIVE INTENT Initial surgery preferred (wide excision with 1 cm margins & supra-omohyoid neck dissection (Level I – III) with reconstruction OR Radical radiation therapy OPTIONS WITH CURATIVE INTENT Initial surgery: wide excision with 1 cm margins + comprehensive neck dissection and reconstruction OR Chemoradiation OR Neo-adjuvant CT followed by surgery INDICATIONS FOR ADJUVANT RT Close margin, positive node(s), or presence of any two of following: LVI, PNI, high grade INDICATIONS FOR ADJUVANT CT-RT: Metastatic nodes |
| What is the purpose of formulating treatment algorithms for medical and surgical conditions in India? | for both outdoor & indoor patient management at primary, secondary and tertiary levels of India’s healthcare system | To formulate treatment algorithms for common and serious medical & surgical conditions for both outdoor & indoor patient management at primary, secondary and tertiary levels of India’s healthcare system that are scientific, robust and locally contextual. • Participation also from Public Health Specialists Search Strategists Graphic Designers • Review by Editorial Board • Approval by Advisory Committee • Prevalence studies • Global burden of diseases studies • HBP of AB-PMJAY Output ADVISORY COMMITTEE ICMR STW Team Speciality wise Expert Committees Editorial Board Book Web Portal Mobile Apps | 87 | summary | 0.970 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | To formulate treatment algorithms for common and serious medical & surgical conditions for both outdoor & indoor patient management at primary, secondary and tertiary levels of India’s healthcare system that are scientific, robust and locally contextual. | 6 | page=6,block=11 |
| What is the purpose of the broad guidelines prepared by national experts in India? | These broad guidelines are advisory, and are based on expert opinions and available scientific evidence. | These STWs have been prepared by national experts of India with feasibility considerations for various levels of healthcare system in the country. These broad guidelines are advisory, and are based on expert opinions and available scientific evidence. There may be variations in the management of an individual patient based on his/her specific condition, as decided by the treating physician. There will be no indemnity for direct or indirect consequences. Kindly visit our web portal (stw.icmr.org.in) for more information. | 147 | summary | 0.970 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | These STWs have been prepared by national experts of India with feasibility considerations for various levels of healthcare system in the country. These broad guidelines are advisory, and are based on expert opinions and available scientific evidence. There may be variations in the management of an individual patient based on his/her specific condition, as decided by the treating physician. | 3 | page=3,block=1 |
| What are the STWs based on? | expert opinions and available scientific evidence | These STWs have been prepared by national experts of India with feasibility considerations for various levels of healthcare system in the country. These broad guidelines are advisory, and are based on expert opinions and available scientific evidence. There may be variations in the management of an individual patient based on his/her specific condition, as decided by the treating physician. There will be no indemnity for direct or indirect consequences. Kindly visit our web portal (stw.icmr.org.in) for more information. | 201 | relationship | 0.930 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | These broad guidelines are advisory, and are based on expert opinions and available scientific evidence. | 3 | page=3,block=1 | 0.700 | valid |
| What are the classifications for non-metastatic disease? | T1-4, N0-3, M0 | • Metastatic disease Any T, any N, M1 • Non metastatic disease T1-4, N0-3, M0 Do CECT thorax and abdomen • Prophylactic cranial irradiation • Symptomatic & supportive care • Palliative chemotherapy carboplatin + etoposide Clinical examination: • Palpable lymph nodes • Chest wall tenderness • Skeletal tenderness • Pleural effusion IMPORTANT ASSESSMENT PARAMETERS PRESENTATION Age and comorbidities Performance status | 63 | definition | 0.900 | https://www.icmr.gov.in/icmrobject/uploads/STWs/1726568902_oncology_all.pdf | • Metastatic disease Any T, any N, M1 • Non metastatic disease T1-4, N0-3, M0 Do CECT thorax and abdomen • Prophylactic cranial irradiation • Symptomatic & supportive care • Palliative chemotherapy carboplatin + etoposide Clinical examination: • Palpable lymph nodes • Chest wall tenderness • Skeletal tenderness • Pleural effusion IMPORTANT ASSESSMENT PARAMETERS PRESENTATION Age and comorbidities Performance status | 9 | page=9,block=11 | 0.700 | valid |